ASAN Lab Research Interests
ResearchÌýofÌý‘Love Hormone’ Shows It Could Hold KeyÌýtoÌýTreatingÌýCOVID-19
Dr. Elissar Andari, assistant professor in the Department of Psychiatry, led a recent study that found
that oxytocin may have potential as a targeted treatment for cytokine storms in COVID-19
patients.
Dr. Andari’s research team, which includedÌýAli Imami, a graduate student in our Bioinformatics program, used a National Institutes of
Health database to analyze characteristics of genes treated with drugs closely related
to oxytocin. They found that one drug in particular, carbetocin, has similar characteristics
(called a signature) to genes with reduced expression of the inflammatory markers
that trigger cytokine storm in COVID-19 patients.
"Understanding the mechanisms by which oxytocin or the oxytocin system can be a new
immune target is crucial," the authors concluded in their report, which was published
online recently in the journalÌýPhysiological Genomics.
However, Dr. Andari added that "safety and efficacy of intravenous oxytocin in hospitalized
patients with COVID-19 remains to be assessed."
IN THE NEWS:ÌýThe research was recently shared inÌýÌýandÌý.Ìý
Authors on the publication are Ali S. Imami, Dr. Sinead M. O’Donovan, Justin F. Creeden,
Xiaojun Wu, Hunter Eby, Dr. Cheryl B. McCullumsmith, Kerstin Uvnäs-Moberg, Dr. Robert
E. McCullumsmith, and Dr. Elissar Andari.